The culture medium utilized in mesenchymal stem cell cultivation contains a diverse array of physiologically active substances released by the stem cells. Stem cell culture supernatant therapy harnesses these potent components by collecting and purifying the culture media, removing impurities. This innovative approach is anticipated to yield effects comparable to traditional stem cell therapy. Notably, it has garnered global attention for being both safe and cost-effective.

Our clinic is at the forefront of incorporating this innovative treatment method—stem cell culture supernatant treatment into our comprehensive approach. This promising therapy is applied effectively in addressing various diseases, enhancing overall physical well-being, and promoting anti-aging benefits.

While global research on induced pluripotent stem (iPS) cells is advancing steadily, practical applications are limited, with only a few exceptions. In contrast, mesenchymal stem cell treatments, utilizing cells naturally present in everyone’s body, have found practical applications in Japan under the Act on the Safety of Regenerative Medicine.

Mesenchymal stem cells, found in various tissues such as fat, deciduous dental pulp, umbilical cord, and bone marrow, possess the unique ability to differentiate into diverse cell types. Our clinic is actively preparing to offer treatments using mesenchymal stem cells derived from the patient’s own subcutaneous fat, providing a promising avenue for regenerative medicine.

1. NMN (nicotinamide mononucleotide; a member of the globally popular vitamin B3 family), which activates the longevity/anti-ageing gene sirtuin, thereby making you feel young and energetic from the cellular level.
2. an herbal mix that inhibits glycation, the root cause of ageing and disease, as well as oxidation, and breaks down and excretes accumulated glycation products (AGE).
3. mucuna bean extract containing ℓ-dopa, which enhances mood and motivation
4. yam extract containing DHEA (diosgenin), an anti-ageing hormone
   a high concentration of these four ingredients.

1. NMN (nicotinamide mononucleotide; a member of the vitamin B3 family that is attracting worldwide attention), which activates the longevity/anti-aging gene sirtuin, thereby making people younger and more energetic from the cellular level
2. an herbal mix that inhibits glycation, the root cause of aging and disease, as well as oxidation, and decomposes and excretes accumulated glycation products (AGE)
3. mucuna bean extract containing ℓ-dopa, which enhances mood and motivation
4. yam extract containing DHEA (diosgenin), an anti-aging hormone
5. black ginger (black turmeric), which has a strong energetic, fatigue-relieving, and anti-obesity effect
6. black pepper, which contains nutrients such as sesaminoglinan with strong antioxidant properties, vitamins and minerals, and increases the absorption rate of the ingredients in the formula.

The above four ingredients of the conventional version are added with black ginger and black pepper, and the amount of NMN is greatly increased (500mg/day).

The carbon dioxide laser is a treatment that can remove raised moles and warts. The CO2 laser is immediately absorbed by moisture and converted to heat energy. When the laser is applied to a mole or wart, the moisture contained in the cells absorbs the laser energy and instantly removes the tissue forming the mole or wart through transpiration. At the same time, the blood vessels around the tissue harden due to the thermal coagulation effect, so there is almost no bleeding. In addition, the transpiration effect of the CO2 laser is only on the superficial side of the skin, and the skin heals quickly.
It does not cause unnecessary damage to the surrounding skin or tissues deep within the skin. Compared to incisions using a scalpel, scarring is less likely to occur, making this an easy treatment.

For the following people

• For those who want to remove moles.
• Those who wish to remove warts.

Expected Effects

• Removal of moles and warts
  *If the treatment is not completed in one session, the second session is free of charge.

LOH (male menopause) syndrome is a condition in which various mental and physical symptoms appear against the background of age-related decline in male hormone (testosterone). Typical symptoms include depression, insomnia, muscle weakness, fatigue, decreased libido, and decreased morning stiffness, with those who are particularly meticulous said to be at higher risk of developing the syndrome.

Japan has set its own reference values, with free testosterone levels of
Treatment is indicated when the free testosterone level is less than 8.5 pg/ml.
If the free testosterone level is between 8.5 and 11.8 pg/ml, it is considered to be in the gray zone.
8.5 to 11.8 pg/ml is considered to be in the gray zone. However, since the value does not always correspond to the severity of symptoms, the severity of symptoms is comprehensively taken into consideration when making a diagnosis.

In our clinic, testosterone replacement therapy (injections or topical medications) is administered once every 2 to 4 weeks after first confirming free testosterone levels and the presence of prostate cancer (PSA levels) through blood tests.

The immune system works through the collaboration of various types of cells, each fulfilling its unique role.
The 6-Type Combination Immunotherapy enhances the body’s power to fight cancer by collecting six types of immune cells—Dendritic Cells (the commanders of the immune system), Natural Killer (NK) Cells, NKT Cells, Killer T Cells, Helper T Cells, and γδ T Cells—from the patient’s blood. These cells are then multiplied and activated outside the body before being reinfused, boosting the immune response against cancer.

・Classified as Category 3 Regenerative Medicine by the Ministry of Health, Labour and Welfare (MHLW) of Japan
・Can be combined with standard cancer treatments
・Applicable to almost all types of cancer
・Not only provides anti-cancer effects but also helps reduce the side effects of chemotherapy and improves the patient’s quality of life
・A gentle treatment with minimal side effects (administered through a 30-minute intravenous drip in an outpatient setting)

Fascia is a membrane-like tissue that covers all the organs, bones, blood vessels, and muscles of the body. Because of its strong image as a membrane that envelopes muscles, fascia is often used as a replacement for fascia, but it also exists in areas other than muscles. The general term for the membranes that wrap everything in the body is “fascia. Recent research has shown that this fascia plays an important role in the smooth movement of the body and is involved in somatic pain. Fascia release” involves ultrasonically locating the area where the fascia is adhered and injecting saline solution into the area to peel (release) the adhered membrane threads. By releasing, the adhered fascia is peeled off, and the stiffened muscles are loosened and movement is improved.

For the following peaple

• Those with stiff shoulders and neck
• Those who have poor joint movement (e.g., shoulder joint periarthritis contracture, sprain, sports injury, etc.)
• Those with lower back pain.
• Those with spring toe, tendonitis, carpal tunnel syndrome
• TMJ arthritis
• Migraine headaches
• Those who have been to an orthopedist but cannot get rid of the pain.

Expected Effects

• Improvement of pain, range of motion of joints, and gliding of muscles

Prolotherapy enhances self-repair capabilities by artificially inducing inflammation and the cell proliferation necessary for wound healing. It can also be a treatment method that strengthens damaged areas such as ligaments and leads to recovery. In addition to the aforementioned effects, the use of highly concentrated glucose solution in our clinic can also provide analgesic effects.

For the following peaple

• Osteoarthritis of the knee (mild cases)
• Sports injuries (ligament injuries)
• Other joint and muscle pain sufferers

Expected Effects

• Pain-relieving effect
• Tissue recovery effect by cell proliferation

Arterial injection therapy is the direct injection of particles (imipenem cilastatin) used as an antibiotic through the arteries of the wrist, elbow or the base of the foot. By clogging the “new blood vessels” involved in pain with the particles, the purpose is to kill them and improve pain.
After injection, the particles dissolve immediately in normal blood vessels, causing no damage to normal blood vessels. This treatment is intended for chronic inflammation such as Heberden’s nodes, thumb CM arthropathy, TFCC, plantar tendonitis, hallux valgus, intractable gout, and Achilles tendonitis.
*The treatment method was developed by Dr. Yuji Okuno of OKUNO Clinic.

For the following people

• Heberden’s nodes
• Tennis elbow, golf elbow
• Osteoarthritis of the knee
• After meniscus injury
• Shoulder joint periarthritis (frozen shoulder)
• Osgood-Schlatter disease
• CM arthritis, TFCC, spring toe, Docherubian tendonitis
• Achilles tendon adhesion inflammation
• Plantar fasciitis
• Patellar tendonitis, etc.
  *Please combine with Phacia Release, Prolotherapy, or Stem Cell Culture Supernatant for maximum effect.

Expected Effects

• Improvement of pain:
  It takes about 3 weeks for the pain to be relieved. It may also take more than 2 times of dynamic injection to achieve improvement.